Once we have established reliable indicators of brain microstructure and optimal approaches to incorporating these to provide robust estimates of brain connectivity, our next and final step of the project was to produce initial reference databases of brain connectivity and microstructure. There have been atlases produced in the past – derived from a single subject – and just using DTI data. Although useful, such atlases tend to be for a single subject. By pooling data from multiple subjects, we will be able to place confidence bounds, in each pixel in the image, on the quantitative metrics of microstructure and connectivity. The atlas will be generated for the developing and adult healthy brain (age range 25-35).
The goals of this part of the project were:
Constructing the first micro-structural atlas in standardized space.
This is the main goal, aim and deliverable of the project; it includes the first ever in-vivo micro-structural atlas of the human and rat brain. In this project aimed to produce a connectivity atlas, and micro-structure atlas of axonal density and myelin water fraction and mean axon diameter.
Links to μatlas files (nifti format)
(A) Averaged FA maps
(D) Averaged MD maps
The summary of this project can be downloaded here